SREBP-1c-Dependent Metabolic Remodeling of White Adipose Tissue by Caloric Restriction

摘要: Caloric restriction (CR) delays the onset of many age-related pathophysiological changes and extends lifespan. White adipose tissue (WAT) is not only a major for energy storage, but also an endocrine that secretes various adipokines. Recent reports have demonstrated alterations in characteristics WAT can impact whole-body metabolism Hence, we hypothesized functional may play important roles beneficial effects CR. Previously, using microarray analysis from CR rats, found enhances fatty acid (FA) biosynthesis, identified sterol regulatory element-binding protein 1c (SREBP-1c), master regulator FA synthesis, as mediator These findings were validated by showing failed to upregulate factors involved biosynthesis extend longevity SREBP-1c knockout mice. Furthermore, revealed implicated CR-associated mitochondrial activation through upregulation peroxisome proliferator-activated receptor γ coactivator-1α (PGC-1α), biogenesis. Notably, these phenotypes observed WAT. We conclude induces SREBP-1c-dependent metabolic remodeling, including enhancement activation, via PGC-1α WAT, resulting effects.