Localized translation near the mitochondrial outer membrane: An update.
作者： Chen Lesnik , Adi Golani-Armon , Yoav Arava
DOI: 10.1080/15476286.2015.1058686
关键词:
摘要: Local synthesis of proteins near their activity site has been demonstrated in many biological systems, and diverse contributions to cellular functions. Studies recent years have revealed that hundreds mitochondria-destined are synthesized by cytosolic ribosomes the mitochondrial outer membrane, indicating localized translation also occurs at this locus. Furthermore, last year central factors involved process were identified yeast, Drosophila, human cells. Herein we review experimental evidence for on side membrane; addition, describe discuss conservation mechanism among various species. We relationship between import into mitochondria suggest avenues study look beyond cotranslational import. Finally future challenges characterizing mechanisms its physiological significance.
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