A role for aquaporin-4 in fluid regulation in the inner retina.

摘要: Many diverse retinal disorders are characterized by edema; yet, little experimental attention has been given to understanding the fundamental mechanisms underlying and contributing these fluid-based disorders. Water transport in out of cells is achieved specialized membrane channels, with most rapid water regulated transmembrane channels known as aquaporins (AQPs). The predominant AQP mammalian retina AQP4, which expressed on Muller glial cells. have previously shown modulate neuronal activity modifying concentrations ions, neurotransmitters, other neuroactive substances within extracellular space between inner outer limiting membrane. In doing so, maintain homeostasis, especially regard spatial buffering potassium (K+) via inward rectifying K+ (Kir channels). Recent studies through highlighted involvement both AQP4 Kir regulating environment brain retina. As functions associated activation, controversy exists literature whether relationship functionally dependent. It argued this review that likely be conduit for facilitating fluid homeostasis during light also play a consequent role regulation ocular volume growth. research already level expression environmentally driven manipulations development myopia.