A potential new radiopharmaceutical for parathyroid imaging: Radiolabeled parathyroid-specific monoclonal antibody—I. Evaluation of 125I-labeled antibody in a nude mouse model system
作者： William G. Cance , Fyllis L. Otsuka , William G. Dilley , Randy W. Scott , Joseph M. Davie
DOI: 10.1016/0883-2897(88)90110-9
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摘要: Abstract Radioiodinated BB5-G1, a parathyroid-specific monoclonal antibody, and its F(ab′)2 Fab fragments were characterized using nude mouse model system. Blood clearance studies indicated that the most slowly clearing species was 125I-BB5-G1 intact while rapidly one 125I-Fab fragment. 125I-F(ab′)2 retained capacity to localize in human parathyroid tissue implants with uptake at 24 h being similar observed antibody. Poor localization These results suggest BB5-G1 or fragment may be useful for imaging.
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