Neuroendocrine Regulation of Leptin Secretion and Its Role in Nitric Oxide Secretion
作者： S. M. McCann , S. Karanth , W. H. Yu , C. A. Mastronardi
DOI: 10.1007/978-1-4615-0157-2_2
关键词:
摘要: In mammals hypothalamic control of gonadotropin secretion is mediated by mammalian luteinizing hormone-releasing hormone (mLHRH), or gonadotropin-releasing (GnRH) and a follicle-stimulating (FSH) RH that IGnRH-III closely related polypeptide. We believe the differential pulsatile release FSH LH its at different times estrous cycle are accounted for FSHRH LHRH. Both LHRH act on gonadotropes to increase intracellular free calcium combines with calmodulin activate neural nitric oxide synthase (nNOS). The NO released activates guanylyl cyclase converts guanosine triphosphate (GTP) into cyclic monophosphate (cGMP) induces exocytosis gonadotropin-containing secretory granules. adipocyte leptin has equal potency from male rat pituitaries NO. It also releases arcuate-nuclear median eminence explants ovariectomized, estrogen-blocked rats, whereas it inhibits same preparation these actions brought about via NO, which controls stimulated other means. Just prior proestrus, sensitivity LH-releasing action peaks suggesting plays role in induction puberty.
springer.com
sci-hub.st 参考文章(99)
M M Klinger, C N Boozer, G D MacCarter, Body weight and composition in the Sprague Dawley rat: comparison of three outbred sources. Laboratory Animal Science. ,vol. 46, pp. 67- 70 ,(1996)
Samuel M McCann, Mayumi Kimura, Wen H Yu, Claudio A Mastronardi, Valeria Rettori, Sharada Karanth, Cytokines and pituitary hormone secretion. Vitamins and Hormones Series. ,vol. 63, pp. 29- 62 ,(2001) , 10.1016/S0083-6729(01)63002-4
Sergio R. Ojeda, James E. Griffin, Textbook of endocrine physiology Oxford University Press. ,(1992)
Claudio A. Mastronardi, Wen H. Yu, Samuel M. McCann, Comparisons of the effects of anesthesia and stress on release of tumor necrosis factor-alpha, leptin, and nitric oxide in adult male rats. Experimental Biology and Medicine. ,vol. 226, pp. 296- 300 ,(2001) , 10.1177/153537020122600405
Susanna Iossa, Lillà Lionetti, Maria Pina Mollica, Antonio Barletta, Giovanna Liverini, Energy intake and utilization vary during development in rats. Journal of Nutrition. ,vol. 129, pp. 1593- 1596 ,(1999) , 10.1093/JN/129.8.1593
G Chaudhuri, H M Vargas, L J Ignarro, J M Cuevas, Comparison of the inhibitory potencies of N(G)-methyl-, N(G)-nitro- and N(G)-amino-L-arginine on EDRF function in the rat: evidence for continuous basal EDRF release. Journal of Pharmacology and Experimental Therapeutics. ,vol. 257, pp. 1208- 1215 ,(1991)
W.L Dees, J.K Hiney, S.A Sower, W.H Yu, S.M McCann, Localization of immunoreactive lamprey gonadotropin-releasing hormone in the rat brain☆ Peptides. ,vol. 20, pp. 1503- 1511 ,(1999) , 10.1016/S0196-9781(99)00162-X
SAMUEL M. McCANN, UMEKO MARUBAYASHI, HUI-QIAO SUN, WEN H. YU, Control of follicle-stimulating hormone and luteinizing hormone release by hypothalamic peptides. Annals of the New York Academy of Sciences. ,vol. 687, pp. 55- 59 ,(1993) , 10.1111/J.1749-6632.1993.TB43853.X
MICHAEL D. LUMPKIN, SAMUEL M. McCANN, Effect of Destruction of the Dorsal Anterior Hypothalamus on Follicle-Stimulating Hormone Secretion in the Rat Endocrinology. ,vol. 115, pp. 2473- 2480 ,(1984) , 10.1210/ENDO-115-6-2473
Helen F. Evans, John Shine, Human Galanin: Molecular Cloning Reveals a Unique Structure Endocrinology. ,vol. 129, pp. 1682- 1684 ,(1991) , 10.1210/ENDO-129-3-1682