Human Galanin: Molecular Cloning Reveals a Unique Structure

摘要: Galanin, a novel neuropeptide/hypothalamic hormone originally identified and isolated by virtue of its carboxyterminal amide group, has recently been shown to have diverse range biological activities, including potent effects on the secretion insulin growth hormone. The physiological role galanin remains unclear, with different being observed when porcine rat used in various animal model systems human studies. Molecular cloning cDNA encoding mRNA associated peptide (GMAP) from both pituitary neuroblastoma sources revealed unique unexpected structure. In contrast porcine, bovine rodent galanin, lacks carboxy-terminal amide. By analogy other neurohormones, absence amidation would be expected significant functional properties such as affinity for receptor subtypes half life, may responsible species specif...