Methods for preparing benzo ring derivative with benzylic quaternary carbon center and ethazocine hydrobromide

摘要: The invention provides methods for preparing a benzo ring derivative with benzylic quaternary carbon center and ethazocine hydrobromide. An aryl iodide an alkylating agent as starting materialsare stirred reaction in organic solvent at 30 DEG C to 120 under the action of palladium catalyst, phosphine ligand, norbornene derivative, base obtain center. raw materials used method are cheap easy obtain, conditions mild, substrate universality is good, yield high, preparation process simple. Meanwhile, present also synthesizing hydrobromide compound based on 1,2,3,4-tetrahydronaphthalene having abenzylic all-carbon synthesized by method, drug treatment cancer pain post-operative can be only four steps. has short synthetic steps, simple operation high total yield.