Pharmacokinetics of furosemide in man after intravenous and oral administration. Application of moment analysis
作者： M. M. Hammarlund , L. K. Paalzow , B. Odlind
DOI: 10.1007/BF00630286
关键词:
摘要: Furosemide 40 mg was administered to 8 healthy subjects as an i.v. bolus dose, 1 tablet in the fasting state, and a solution after food intake. The data gave total body clearance of 162 +/- 10.8 ml/min renal 117 11.3 ml/min; volume distribution at steady state 8.3 0.61. Oral administration bio-availability (fasting) 51%. Food intake slightly reduced bioavailability, but not significant extent. There no difference availability between solution. Moment analysis mean residence time MRTi .v., 51 1.5 min. absorption times (MAT) for all oral doses were significantly longer than indicating rate-limited kinetics furosemide. On average, delayed by 60 MAT postprandial solution, dissolution tablet.
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sci-hub.se 参考文章(16)
W. Rupp, Pharmacokinetics and Pharmacodynamics of Lasix Scottish Medical Journal. ,vol. 19, pp. 5- 13 ,(1974) , 10.1177/00369330740190S103
D E Smith, E T Lin, L Z Benet, Absorption and disposition of furosemide in healthy volunteers, measured with a metabolite-specific assay. Drug Metabolism and Disposition. ,vol. 8, pp. 337- 342 ,(1980)
Sidney Riegelman, Paul Collier, The application of statistical moment theory to the evaluation of in vivo dissolution time and absorption time Journal of Pharmacokinetics and Biopharmaceutics. ,vol. 8, pp. 509- 534 ,(1980) , 10.1007/BF01059549
Thomas N. Tozer, Concepts basic to pharmacokinetics. Pharmacology & Therapeutics. ,vol. 12, pp. 109- 131 ,(1981) , 10.1016/0163-7258(81)90077-2
F. Andreasen, C. Kjeldahl Christensen, F. Kjaer Jakobsen, C. E. Mogensen, The use of HPLC to elucidate the metabolism and urinary excretion of furosemide and its metabolic products. Pharmacology & Toxicology. ,vol. 49, pp. 223- 229 ,(2009) , 10.1111/J.1600-0773.1981.TB00897.X
M. M. Hammarlund, L. K. Paalzow, Dose-dependent pharmacokinetics of furosemide in the rat Biopharmaceutics & Drug Disposition. ,vol. 3, pp. 345- 359 ,(1982) , 10.1002/BDD.2510030408
F. ANDREASEN, C. KJELDAHL CHRISTENSEN, F. KJAER JACOBSEN, J. JANSEN, C. E. MOGENSEN, O. LEDERBALLE PEDERSEN, The individual variation in pharmacokinetics and pharmacodynamics of furosemide in young normal male subjects European Journal of Clinical Investigation. ,vol. 12, pp. 247- 255 ,(1982) , 10.1111/J.1365-2362.1982.TB01000.X
Ralph E. Cutler, Andrew D. Blair, Clinical Pharmacokinetics of Frusemide Clinical Pharmacokinectics. ,vol. 4, pp. 279- 296 ,(1979) , 10.2165/00003088-197904040-00002
Vinod S Chungi, Lewis W Dittert, Randall B Smith, None, Gastrointestinal sites of furosemide absorption in rats International Journal of Pharmaceutics. ,vol. 4, pp. 27- 38 ,(1979) , 10.1016/0378-5173(79)90095-4
Leslie Z. Benet, Renato L. Galeazzi, Noncompartmental Determination of the Steady‐State Volume of Distribution Journal of Pharmaceutical Sciences. ,vol. 68, pp. 1071- 1074 ,(1979) , 10.1002/JPS.2600680845