The influence of food intake on the effect of two controlled release formulations of furosemide.

摘要: Differences in the urinary excretion rate of furosemide may explain discrepancies observed between bioavailability and total diuretic effect different formulations this drug. Furosemide was given at a dose 60 mg as two oral controlled release (CR) (FR LR), with without breakfast, randomized, four-treatment, four-period, crossover design to 28 healthy volunteers. Urinary volume, contents sodium, were measured samples taken over 24 h. The extent absorption from FR decreased after breakfast compared fasting: mean (SD) excreted 11.38 (3.12) 7.73 (1.67) mg, p < 0.0001, median (range) residence time increased 6.3 (4.1-9.3) 9.5 (5.9-11.8) h, 0.001. On other hand, LR 8.04 (3.32) 9.45 (1.83) 0.05, significant change MRT. had higher than during fasting, but its lower that postprandial state. Interestingly, fraction absorbed, estimated excretion, not correlated diuresis (r2 = 0.079) differences drug response among four periods much smaller would be expected amount absorbed. This discrepancy explained by and, related this, efficiency profiles treatments. Therefore, profile formulation more important for cumulated