The C Terminus of HIV-1 Tat Modulates the Extent of CD178-mediated Apoptosis of T Cells
作者： Grant R. Campbell , Jennifer D. Watkins , Didier Esquieu , Eddy Pasquier , Erwann P. Loret
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摘要: HIV infection and the progression to AIDS are characterized by depletion of CD4(+) T cells through apoptosis uninfected bystander direct killing HIV-infected cells. This is mediated in part human immunodeficiency virus, type 1 Tat protein, which secreted virally infected taken up CD178 gene expression, critically involved cell apoptosis. The differing ability strains induce death may play a role clinical biological differences displayed strains. We chemically synthesized 86-residue truncated short variant its full-length form. show that trans-activation at long terminal repeat does not correlate with but up-regulate mRNA expression dependent on C terminus Tat. Moreover, greater Tat-induced via extrinsic pathway CD95-CD178.
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