Tat mutations in an African cohort that do not prevent transactivation but change its immunogenic properties

摘要: Humoral responses against extra-cellular HIV-1 Tat may be beneficial as has been implicated in the viral pathogenesis associated with disease progression. We determined levels of anti-Tat IgG sera seropositive individuals from Rural Clinical Cohort Uganda using nine different proteins representative major subtypes presently accounting for 97% infections worldwide. observed presence able to react various tested, although none cross-reacted all variants. show that 46.25% patients were recognise at least one variant 1:1000 dilution. also C terminus is most variable region and an important epitope might explain limitation cross-recognition antibodies regarding This study shows can tolerate mutations without modification its primary function but changes immunogenic properties. These findings should considered when designing Tat-based vaccines.