An atypical presentation of visceral leishmaniasis infection in a patient with rheumatoid arthritis treated with infliximab.

摘要: Tumor necrosis factor alpha (TNF-alpha) is a cytokine, implicated in the pathogenesis of many inflammatory diseases, as well immune-mediated response to infection, especially against intracellular pathogens. TNF-alpha antagonists have represented revolution management connective tissue such rheumatoid arthritis. However, use these agents has been with emergence growing number opportunistic infections. Here we report case visceral Leishmaniasis 77-year-old woman who had previously treated for arthritis infliximab. The atypical presentation this patient, an anti-TNF-alpha biologic agent, where no splenomegaly or hepatomegaly was identified, emphasized.