Calling in sick: impacts of fever on intra-urban human mobility.

摘要: Pathogens inflict a wide variety of disease manifestations on their hosts, yet the impacts behaviour infected hosts are rarely studied empirically and seldom accounted for in mathematical models transmission dynamics. We explored potential one most common manifestations, fever, key determinant pathogen transmission, host mobility, residents Amazonian city Iquitos, Peru. did so by comparing two groups febrile individuals (dengue-positive dengue-negative) with an afebrile control group. A retrospective, semi-structured interview allowed us to quantify multiple aspects mobility during two-week period preceding each interview. fitted nested aspect data from interviews compared using likelihood ratio tests determine whether there were statistically distinguishable differences attributable fever or its aetiology. Compared individuals, study participants spent more time at home, visited fewer locations, and, some cases, locations closer home less certain types locations. These multifaceted consistent possibility that disease-mediated changes generate dynamic complex contact network structure.