Sustained prevention of biofilm formation on a novel silicone matrix suitable for medical devices.

摘要: Bacterial colonization and biofilm formation on medical devices constitute major challenges in clinical long-term use of e.g. catheters due to the risk (re)infection patients, which would result additional antibiotics risking bacterial resistance development. The aim present project was introduce a novel antibacterial approach involving an advanced composite material applicable for devices. polymeric composites investigated consisted hydrogel network cross-linked poly(2-hydroxyethyl methacrylate) (PHEMA) embedded poly(dimethylsiloxane) (PDMS) silicone elastomer produced using supercritical carbon dioxide (scCO2). In these materials, may contain active pharmaceutical ingredient while provides sufficient mechanical stability material. conceptual studies, antimicrobial agent ciprofloxacin loaded into polymer matrix by post-polymerization loading procedure. Sustained release demonstrated, could be controlled varying content range 13-38% (w/w) changing concentration during 1-20mg/mL. Devices containing 25% with displayed strong effect against Staphylococcus aureus subsequent device inhibited 29days. conclusion, hydrogel/silicone represents promising candidate that prevent use.