N-cyclopropane substituent-containing curcumin analogue and drug application thereof
作者： Tang Mosheng , Wang Lihua , Chen Tongke
DOI:
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摘要: The invention discloses an N-cyclopropane substituent-containing curcumin analogue. molecular expression of the analogue is (3E,5E)-3-(3-allyl-4-hydroxyl benzylidene)-1-cyclopropyl-5-(2,4-dimethoxy benzylidene)piperidine-4-ketone. further drug application applied to prevention or treatment sepses induced by bacteria and inflammatory reactions chemical substances, wherein comprise factor release lipopolysaccharide (LPS) septic death LPS, substances ear swelling xylene, vascular permeability increasing caused intraperitoneal injection acetic acid twisting number acid.
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