Compositions and methods for treating cancer and diseases and conditions responsive to growth factor inhibition

作者: David Cheresh , Laetitia Seguin

DOI:

关键词: PharmacologyCellMedicineLenalidomideGrowth Factor InhibitionCancerGrowth factorCancer cellIκB kinaseBortezomib

摘要: In alternative embodiments, the invention provides compositions and methods for overcoming or diminishing preventing Growth Factor Inhibitor resistance in a cell, or, method increasing growth-inhibiting effectiveness of inhibitor on re-sensitizing cell to Inhibitor. is tumor cancer dysfunctional cell. determining: whether an individual patient would benefit from respond administration Inhibitor, which individuals patients combinatorial approach comprising combination of: at least one growth factor compound, composition formulation used practice invention, such as NFKB inhibitor, lenalidomide REVLIMID TM , bortezomib VELCADE®, IKK inhibitor.