Lipoprotein lipase activity and its relationship to high milk fat transfer during lactation in grey seals

摘要: Lipoprotein lipase regulates the hydrolysis of circulating triglyceride and uptake fatty acids by most tissues, including mammary gland adipose tissue. Thus, lipoprotein is critical for secretion long-chain in milk assimilation a high-fat diet suckling young. In lactating female, appears to be regulated such that levels tissue are almost completely depressed while those high. directed fat production. Phocid seals serve as excellent models study transfer during lactation because mothers may fast secreting large quantities high milks pups deposit amounts blubber. We measured pup body composition intake isotope (deuterium oxide) dilution plasma post-heparin activity six grey seal (Halichoerus grypus) mother-pup pairs at birth again late 16-day laction period. Maternal increased an average four-fold (P=0.027), which paralleled increase concentration (from 38 56%; P=0.043). Increasing was correlated with increasing output (1.3–2.1 kg per day) over (P=0.019). (during fasting) inversely (P=0.027) associated direct incorporation longchain from blubber into milk. pups, already total content (P=0.028) ratio fat: protein incrased (P=0.036) lactation. Although daily (P=0.023), effectively cleared lipid circulation deposited 70% consumed throughout play important role mechanisms involved extraordinary rates phocid seals.