Autophagy is required for stem cell mobilization by G-CSF

摘要: Granulocyte colony-stimulating factor (G-CSF) is widely used clinically to prevent neutropenia after cytotoxic chemotherapy and mobilize hematopoietic stem cells (HSCs) for transplantation. Autophagy, a process of cytoplasmic component recycling, maintains cellular homeostasis protects the cell during periods metabolic stress or nutrient deprivation. We have observed that G-CSF activates autophagy in neutrophils HSCs from both mouse human donors. Furthermore, G-CSF–induced neutrophil HSC mobilization impaired absence autophagy. In contrast, dispensable direct response CXCR4 antagonist AMD3100. Altogether, these data demonstrate an important role invoking within myeloid suggest this pathway critical ensuring survival relevant cytokine-induced stress. These findings relevance transplantation increasing clinical use agents modulate