Management of cutaneous melanoma M0: state of the art and trends

摘要: This article reviews the epidemiology, diagnosis and treatment of cutaneous melanoma, including most recent developments. The combination positive family history, fair complexion, number nevi, exposure to sun and/or chromosomal alterations seem be implicated in pathogenesis melanoma. Melanomas can classified according their growth patterns, tumour microstaging is straightforward predictive value for survival risk metastasis, although new factors are also being investigated. As yet, surgical excision only effective available primary tumours, resection margins varying thickness. Elective node dissection is, however, no longer advocated melanomas thinner than 1.5 mm, there disagreement as its role thicker lesions. In contrast, selective at time definitive surgery becoming more widely accepted, with regional restricted cases. Therapeutic required lymph involvement, common pattern recurrence from which affects nearly 30% all patients. Complete remission rates isolated limb perfusion, has been employed patients multiple recurrences or in-transit metastases, range 40 90%, depending on drugs techniques used different series; best responses so far have obtained necrosis factor melphalan. Patients thick lesions (> 4 mm) metastases a high micrometastases that would warrant adjuvant therapy. agent found affect interferon alpha-2.