Effect of cadmium on bone tissue in growing animals.
作者： Juliana Rodríguez , Patricia Mónica Mandalunis
DOI: 10.1016/J.ETP.2016.06.001
关键词:
摘要: Accumulation of cadmium (Cd), an extremely toxic metal, can cause renal failure, decreased vitamin D synthesis, and consequently osteoporosis. The aim this work was to evaluate the effect Cd on two types bone in growing Wistar rats. Sixteen 21-day-old male rats were assigned one groups. group subcutaneously received 0.5mg/kg CdCl2 5 times weekly for 3 months. control similarly bidistilled water. Following euthanasia, mandibles tibiae resected, fixed, decalcified processed histologically obtain sections H&E tartrate-resistant acid phosphatase (TRAP) staining. Photomicrographs used determine volume (BV/TV%), total growth cartilage width (GPC.Wi) hypertrophic (HpZ.Wi), percentage yellow marrow (%YBM), megakaryocyte number (N.Mks/mm(2)), TRAP+osteoclast (N.TRAP+Ocl/mm(2)). Results statistically analyzed using Student's t test. exposed animals showed a significant decrease subchondral increase TRAP+ osteoclast tibia, mandibular interradicular bone. No differences observed remaining parameters. results obtained with experimental design show that would seemingly have different tibial suggest inhibits differentiation mesenchymal cells osteoblasts, favoring into adipocytes. effects might be due protective mastication forces.
sci-hub.se 参考文章(43)
Jin Hao, Yueling Zhang, Dian Jing, Yu Shen, Ge Tang, Shishu Huang, Zhihe Zhao, Mechanobiology of mesenchymal stem cells: Perspective into mechanical induction of MSC fate Acta Biomaterialia. ,vol. 20, pp. 1- 9 ,(2015) , 10.1016/J.ACTBIO.2015.04.008
Hideaki Nakagawa, Muneko Nishijo, Yuko Morikawa, Katsuyuki Miura, Kenji Tawara, Jun-ichi Kuriwaki, Teruhiko Kido, Akemi Ikawa, Etsuko Kobayashi, Koji Nogawa, Urinary cadmium and mortality among inhabitants of a cadmium-polluted area in Japan. Environmental Research. ,vol. 100, pp. 323- 329 ,(2006) , 10.1016/J.ENVRES.2005.08.014
Xiao Chen, Guoying Zhu, Taiyi Jin, Shuzhu Gu, Hanfang Xiao, Jing Qiu, Cadmium induces differentiation of RAW264.7 cells into osteoclasts in the presence of RANKL. Food and Chemical Toxicology. ,vol. 49, pp. 2392- 2397 ,(2011) , 10.1016/J.FCT.2011.06.053
Li Guan, Yan-Lin Zhang, Tao Wen, Xi-Fu Wang, Ming-Xia Zhu, Jin-Yuan Zhao, Dynamic Changes of Heme Oxygenase-1 in the Hippocampus of Rats After Acute Carbon Monoxide Poisoning Archives of Environmental Contamination and Toxicology. ,vol. 60, pp. 165- 172 ,(2011) , 10.1007/S00244-010-9524-3
Jia Liu, Zuo-lin Jin, Qiang Li, Effect of occlusal hypofunction and its recovery on the three-dimensional architecture of mandibular alveolar bone in growing rats. Journal of Surgical Research. ,vol. 193, pp. 229- 236 ,(2015) , 10.1016/J.JSS.2014.07.015
Clifford J Rosen, Mary L Bouxsein, Mechanisms of disease: is osteoporosis the obesity of bone? Nature Reviews Rheumatology. ,vol. 2, pp. 35- 43 ,(2006) , 10.1038/NCPRHEUM0070
Xiao Chen, Guoying Zhu, Taiyi Jin, Chunlin Shao, Shuzhu Gu, Mingguang Tan, Yanyan Zhang, Hanfang Xiao, Heping Hu, Yunzhen Yu, Bone-Prognostic Status After Cessation of Cadmium Exposure for One Month in Male Rats Archives of Environmental Contamination and Toxicology. ,vol. 62, pp. 165- 175 ,(2012) , 10.1007/S00244-011-9685-8
K. G. Coonse, A. J. Coonts, E. V. Morrison, S. J. Heggland, Cadmium Induces Apoptosis in the Human Osteoblast-like Cell Line Saos-2 Journal of Toxicology and Environmental Health. ,vol. 70, pp. 575- 581 ,(2007) , 10.1080/15287390600882663
Nikhil Johri, Grégory Jacquillet, Robert Unwin, Heavy metal poisoning: the effects of cadmium on the kidney Biometals. ,vol. 23, pp. 783- 792 ,(2010) , 10.1007/S10534-010-9328-Y
Anestis Mavropoulos, Stavros Kiliaridis, René Rizzoli, Patrick Ammann, Normal masticatory function partially protects the rat mandibular bone from estrogen-deficiency induced osteoporosis Journal of Biomechanics. ,vol. 47, pp. 2666- 2671 ,(2014) , 10.1016/J.JBIOMECH.2014.05.012