Bone-Prognostic Status After Cessation of Cadmium Exposure for One Month in Male Rats
作者： Xiao Chen , Guoying Zhu , Taiyi Jin , Chunlin Shao , Shuzhu Gu
DOI: 10.1007/S00244-011-9685-8
关键词:
摘要: This study investigated bone status after decreased cadmium (Cd) exposure in male rats. Sprague–Dawley rats were randomly divided into three groups. One group was injected subcutaneously with sodium chloride as control. The others given CdCl2 by subcutaneous injection at doses of 0.5 mg Cd/kg body weight (bw) for 2 months (Cd+2m) and 3 (Cd+3m). For the Cd+2m group, shifted to cessation Cd 1 month months’ exposure. At 3, micro-computed tomography (micro-CT) analyses performed on proximal tibia lumbar spine, urine collected from all Rats then killed blood metabolic-marker measurement assay. Bone tissues also bone-mass assay, biomechanical test, bone-histology analysis. burdens Cd+3m groups both significantly greater than those control group. lower compared damage occurred (p < 0.05), but no significant improvement found could not be reversed over short term. More attention should paid Cd’s toxic effects
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