Glucosylation of human lens protein and cataractogenesis.

摘要: Abstract Examination of glucosylation lens protein was conducted utilizing tritiated BH4−. The overall results indicate that approximately 0.20 moles tritium were incorporated per mole protein. Similar obtained with normal and senile cataractous lenses varying degrees opacity. Furthermore no difference in the 3H incorporation observed between soluble insoluble fractions derived from these lenses. Investigation selected polypeptides isolated cataracts gave comparable results. Protein diabetic had only slightly higher levels incorporation, giving an average value 0.27 Analyses products 50% is probably due to reduction other types compounds. These suggest does not appear be a primary factor cataract formation.