CD63 and GLUT-1 Overexpression Could Predict a Poor Clinical Outcome in GIST: A Study of 54 Cases with Follow-Up

摘要: Background and Goals. In light of current knowledge, it seems that alternations underlying GISTs are well explained, although all is enhanced by various aspects on a daily basis. More recently, attention has been pointed towards exosomes as important particles able to modify healthy also diseased tissues including cancer. The goal the present study was an analysis CD9, CD63, GLUT-1 marker hypoxia status within 54 cases GIST evaluation their predictive value. Methods. patients suffering from were enrolled into study, predominantly in gastric location. All operated had no Imatinib other chemotherapies up day operation. Expression targeted proteins performed immunohistochemistry and, after that, results with tabulated clinical data compared Kaplan-Meier method multivariate Cox proportional hazard model statistical analysis. Results. Our presented marked dependence worsening outcome high expression CD63 (p = 0.008) 0.014). We noted strict correlation 0.03), which could confirm thesis about contribution intratumoural status. collected material did not CD9 contribution. Conclusions. As here, have prognostic value cases. studies this scope can be used future additional factor.