Isobutylhydroxyamides from the pericarp of Nepalese Zanthoxylum armatum inhibit NF1-defective tumor cell line growth
作者： Krishna P. Devkota , Jennifer Wilson , Curtis J. Henrich , James B. McMahon , Karlyne M. Reilly
DOI: 10.1021/NP300696G
关键词:
摘要: A neurofibromatosis type 1 (NF1)-based bioassay-guided phytochemical investigation on Zanthoxylum armatum collected in Nepal led to the isolation of new timuramides A-D (1-4) and six known sanshools (5-10). The structures all compounds were established by using modern spectroscopic techniques, including 1D 2D NMR analysis comparison with previously reported data. Most inhibited growth an Nf1- p53-deficient mouse glioma cell line at noncytotoxic concentrations.
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