Synthesis, antifungal activity of caffeic acid derivative esters, and their synergism with fluconazole and nystatin against Candida spp.
作者： Janaína de Cássia Orlandi Sardi , Fernanda Patrícia Gullo , Irlan Almeida Freires , Nayla de Souza Pitangui , Maicon Petrônio Segalla
DOI: 10.1016/J.DIAGMICROBIO.2016.08.002
关键词:
摘要: We tested the antifungal potential of caffeic acid and 8 its derivative esters against Candidaalbicans ATCC 90028 9 clinical isolatesand carried out a synergism assay with fluconazole nystatin. Propyl caffeate (C3) showed best activity strains. When in combination, C3 markedly reduced MIC nystatin synergistic effect up to 64-fold. Finally, high IC50 value selective indexagainst oral keratinocytes, demonstrating low toxicity this cell type selectivity for yeast cells. Further research should confirm development combined therapy treat C. albicans infections.
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