Candida tropicalis bloodstream infection: Incidence, risk factors and outcome in a population-based surveillance

摘要: Summary Objective To assess the current clinical features and determinants of outcome Candida tropicalis bloodstream infection (BSI). Methods A population-based surveillance on BSI was conducted from May 2010 to April 2011 in 29 Spanish hospitals. Antifungal susceptibility testing (EUCAST methodology) centrally performed. The characteristics C. episodes were compared with those due other species. Results Fifty-nine out 752 (7.8%) (annual incidence: 0.62 cases per 100,000 population). Resistance fluconazole voriconazole found 23.2% 26.8% isolates. Breakthrough occurred 10.5% episodes. Risk factors for age (odds ratio [OR]: 1.01; P -value = 0.05), underlying leukaemia (OR: 4.77; -value = 0.001) chronic lung disease 2.62; -value = 0.002). There no differences failure (persistent ≥72 h after initiation therapy and/or 30-day all-cause mortality) between (39.6%) non- groups (45.6%). appropriateness antifungal or MIC values had significant impact outcome, whereas early central venous catheter removal exerted a protective effect. Conclusions associated advanced age, haematological malignancy respiratory comorbidity. We correlation unexpectedly high resistance rate azoles observed outcome.