Inhibition of human placental progesterone and estrogen synthesis in early human gestation by aminoglutethimide in vivo

摘要: Abstract The inhibitory effect of d,l-aminoglutethimide (AG) on the synthesis progesterone and estradiol in early human pregnancy (8th–12th week gestation) was investigated volunteers; control group (n = 11), AG [1000 mg orally at test begin 6)]. Venous blood samples were taken beginning 0.5, 1, 2, 4, 8 24 h thereafter. In controls, no significant changes serum could be observed during h. group, a decrease within 1 after began; lowest steroid concentrations reached 4 Relative to initial values as 100%, greatest ranged between 37 83%, 62 15% (x SD) 6); 32 78%, 51 17% 6). Twenty four hours treatment, both steroids similar those found begin. No clinical signs (e.g. uterine bleeding, contractions) for abortifacient action observed. conclusion, single dose (1000mg given orally) cannot induce therapeutic abortion pregnancy. accordance with vitro studies, placental formation is due an inhibition mitochondrial cholesterol side chain cleavage. thought related aromatase.