Opioid agonist/opioid antagonist/acetaminophen combinations

摘要: The invention is directed in part to oral dosage forms comprising a combination of an opioid agonist, acetaminophen and orally active antagonist, the antagonist being included ratio agonist provide product which analgesically effective when administered orally, but aversive physically dependent subject. Preferably, amount provides at least mildly negative, “aversive” experience addicts (e.g., precipitated abstinence syndrome).