Palladium-catalyzed addition of mono- and dicarbonyl compounds to conjugated dienes.

摘要: An intermolecular, palladium-catalyzed addition of the α-C−H bond monocarbonyl and 1,3-dicarbonyl compounds to dienes has been developed, an exploration scope these reactions with a broad range carbonyl nitriles was conducted. The combination CpPd(allyl) commercially available 1,3-bis(dicyclohexylphosphino)propane (DCyPP) catalyzed 1:1 C−H bonds substrates in high yields. These included unusual additions ketones, lactones, esters, dienes, as well more common cyanoesters, malononitrile, α-sulfonyl esters. Reactions both cyclic acyclic are reported. by complexes nonracemic chiral ligands were also conducted, first enantioselective version this reaction achieved Josiphos ligand enantioselectivities up 81%.