Changes in the Pulmonary Glucocorticoid Receptor Content in the Course of Interstitial Disease

作者: Paulo Hilàrio Nascimento Saidiva , Maria Mitzi Brentani , Carlos RR de Carvalho , José Otávio , C Auler jr

DOI: 10.1378/CHEST.88.3.417

关键词:

摘要: The level of cytosolic glucocorticoid receptors (GR) was measured in 12 open-chest lung biopsies interstitial pulmonary diseases. results showed an increase the GR content diseased lungs correlated to degree septal cellularity nine cases. Two sarcoidosis and one end-stage idiopathic fibrosis patients presented higher levels than those predicted by cellularity. It concluded that increases course diseases, reflecting number cells express parenchyma.

参考文章(26)
E. Brad Thompson, Aniko Venetianer, Thomas D. Gelehrter, Gordon Hager, Darryl K. Granner, Michael R. Norman, Thomas J. Schmidt, Jeffrey M. Harmon, Multiple Actions of Glucocorticoids Studied in Cell Culture Systems Springer, New York, NY. pp. 126- 152 ,(1980) , 10.1007/978-1-4612-6054-7_9
Loring We, Felton Wl rd, Liebow Aa, The musculature of the lungs in chronic pulmonary disease. American Journal of Pathology. ,vol. 29, pp. 885- 911 ,(1953)
PHILIP L. BALLARD, ROBERT J. MASON, WILLIAM H. J. DOUGLAS, Glucocorticoid binding by isolated lung cells. Endocrinology. ,vol. 102, pp. 1570- 1575 ,(1978) , 10.1210/ENDO-102-5-1570
George Giannopoulos, Katharine Jackson, Dan Tulchinsky, Specific glucocorticoid binding in human uterine tissues, placenta and fetal membranes Journal of Steroid Biochemistry. ,vol. 19, pp. 1375- 1378 ,(1983) , 10.1016/0022-4731(83)90166-8
G. Hochhaus, P. Rohdewald, H. Möllmann, D. Greschuchna, Identification of glucocorticoid receptors in normal and neoplastic adult human lung Research in Experimental Medicine. ,vol. 182, pp. 71- 78 ,(1983) , 10.1007/BF01852289
MM Brentani, MA Nagai, CT Fujiyama, JCS Goes, None, Steroid receptors in a group of Brazilian breast cancer patients. Journal of Surgical Oncology. ,vol. 18, pp. 431- 439 ,(1981) , 10.1002/JSO.2930180411
M.M. Brentani, C. R.R. Carvalho, P.H. Saldiva, M.M. Pacheco, C. T.F. Oshima, Steroid receptors in pulmonary lymphangiomyomatosis. Chest. ,vol. 85, pp. 96- 99 ,(1984) , 10.1378/CHEST.85.1.96
P L Ballard, R A Ballard, Cytoplasmic receptor for glucocorticoids in lung of the human fetus and neonate. Journal of Clinical Investigation. ,vol. 53, pp. 477- 486 ,(1974) , 10.1172/JCI107581
K B Horwitz, L D Horwitz, Canine vascular tissues are targets for androgens, estrogens, progestins, and glucocorticoids. Journal of Clinical Investigation. ,vol. 69, pp. 750- 758 ,(1982) , 10.1172/JCI110513
Peter F. Bruning, Walter J. Meyer, Claude J. Migeon, Glucocorticoid receptor in cultured human skin fibroblasts Journal of Steroid Biochemistry. ,vol. 10, pp. 587- 593 ,(1979) , 10.1016/0022-4731(79)90510-7