Lack of Correlation Between Papillomaviral DNA in Surgical Margins and Recurrence of Equine Sarcoids

摘要: Bovine papillomavirus (BPV) types 1 (BPV-1) and 2 (BPV-2) are causally associated with the development of equine sarcoid tumors. Recurrence rates after surgical excision sarcoids estimated to be 30%–40%. We hypothesized that presence BPV DNA in histologically tumor-free margins is risk recurrence, increased quantity recurrence. Formalin-fixed classified as “completely excised” were obtained from two institutions. A total 25 tumors included, eight which recurred within year excision. Qualitative quantitative polymerase chain reaction (PCR) tests for detection BPV-1 BPV-2 performed on neoplastic tissue formalin-fixed paraffin-embedded biopsy specimens following extraction. papillomavirus-1 was found all tumor samples “clean” 21 samples, whereas only samples. Although PCR more sensitive than qualitative detecting margins, there no significant difference or versus those did not recur either test. this study limited by sample size, our results suggest analysis a reliable method predict recurrence resection.