Critical periods of susceptibility to short-term energy challenge during pregnancy: Impact on fertility and offspring development.

摘要: Abstract In female mammals, reproduction is tightly regulated by energy status and food availability. Although acute energetic challenges inhibit reproductive behavior gonadotropin secretion, less attention has been given to the effects of short-term challenge on pregnancy gestation. Furthermore, species differences in physiology necessitate more detailed analyses specific models. Here, we studied musk shrews, which display induced ovulation obligate delayed implantation, whose linked metabolic status. We tested whether varied degrees at stages (including before after implantation) have different gestational outcome offspring postnatal development. found that 48 h either 40% or 50% restriction, reduced body weight strongly inhibited sexual behavior, had minimal success litter dynamics when administered early gestation (pre-implantation). However,