作者: V. Letscher-Bru , C. M. Obszynski , M. Samsoen , M. Sabou , J. Waller
DOI: 10.1007/S11046-012-9583-2
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摘要: Although sodium bicarbonate—NaHCO3 (SB) has many domestic and medical, traditional empirical uses, only little scientific documentation of its activity is available. The aims this study were to investigate the antifungal SB on three fungal groups (yeasts, dermatophytes molds) responsible for human skin nail infections. We first evaluated in vitro 70 strains isolated from infections: 40 dermatophytes, 18 yeasts 12 molds. A concentration 10 g/L inhibited growth 80 % all isolates tested Sabouraud dextrose agar. minimal inhibitory 90 (MIC90) measured agar, broth potato was 5 g/L yeasts, 20 g/L 40 g/L In a second step, we prospectively ex vivo 24 infected (15 7 2 clinical specimens nails 9 scrapings). completely 19 (79 %) reduced 4 (17 %) after 7 days incubation dextrose–chloramphenicol agar supplemented with as compared without SB. conclusion, documented most common agents cutaneous infection onychomycosis, specified effective concentrations different pathogenic fungi. mechanism action yet be explored.