Antifungal activity of sodium bicarbonate against fungal agents causing superficial infections.

作者: V. Letscher-Bru , C. M. Obszynski , M. Samsoen , M. Sabou , J. Waller

DOI: 10.1007/S11046-012-9583-2

关键词:

摘要: Although sodium bicarbonate—NaHCO3 (SB) has many domestic and medical, traditional empirical uses, only little scientific documentation of its activity is available. The aims this study were to investigate the antifungal SB on three fungal groups (yeasts, dermatophytes molds) responsible for human skin nail infections. We first evaluated in vitro 70 strains isolated from infections: 40 dermatophytes, 18 yeasts 12 molds. A concentration 10 g/L inhibited growth 80 % all isolates tested Sabouraud dextrose agar. minimal inhibitory 90 (MIC90) measured agar, broth potato was 5 g/L yeasts, 20 g/L 40 g/L In a second step, we prospectively ex vivo 24 infected (15 7 2 clinical specimens nails 9 scrapings). completely 19 (79 %) reduced 4 (17 %) after 7 days incubation dextrose–chloramphenicol agar supplemented with as compared without SB. conclusion, documented most common agents cutaneous infection onychomycosis, specified effective concentrations different pathogenic fungi. mechanism action yet be explored.

参考文章(25)
van der Gaag Dj, van Slooten Ma, Dik Aj, Efficacy of salts against fungal diseases in glasshouse crops. Communications in agricultural and applied biological sciences. ,vol. 68, pp. 475- ,(2003)
D A DePasquale, T J Montville, Mechanism by which ammonium bicarbonate and ammonium sulfate inhibit mycotoxigenic fungi. Applied and Environmental Microbiology. ,vol. 56, pp. 3711- 3717 ,(1990) , 10.1128/AEM.56.12.3711-3717.1990
T J Montville, P K Goldstein, Sodium bicarbonate reduces viability and alters aflatoxin distribution of Aspergillus parasiticus in Czapek's agar. Applied and Environmental Microbiology. ,vol. 53, pp. 2303- 2307 ,(1987) , 10.1128/AEM.53.10.2303-2307.1987
Mario Schirra, Salvatore D’Aquino, Amedeo Palma, Alberto Angioni, Paolo Cabras, Factors affecting the synergy of thiabendazole, sodium bicarbonate, and heat to control postharvest green mold of citrus fruit. Journal of Agricultural and Food Chemistry. ,vol. 56, pp. 10793- 10798 ,(2008) , 10.1021/JF802295M
Ik Jun Ko, Chung Won Kim, Won Houh, Ryoji Tsuboi, Kazuko Matsuda, Hideoki Ogawa, Relationship between Candida albicans producing proteinase (CAPP) and its environmental pH--comparison with a case of trichophyton mentagrophytes. Journal of Korean Medical Science. ,vol. 2, pp. 97- 101 ,(1987) , 10.3346/JKMS.1987.2.2.97
Y. Aharoni, E. Fallik, A. Copel, M. Gil, S. Grinberg, J.D. Klein, Sodium bicarbonate reduces postharvest decay development on melons Postharvest Biology and Technology. ,vol. 10, pp. 201- 206 ,(1997) , 10.1016/S0925-5214(97)01412-9
Mrudula Patel, Jo-Anne Shackleton, Maeve M. Coogan, Jacky Galpin, Antifungal effect of mouth rinses on oral Candida counts and salivary flow in treatment-naïve HIV-infected patients. Aids Patient Care and Stds. ,vol. 22, pp. 613- 618 ,(2008) , 10.1089/APC.2007.0160
Lawrence R. Wheeless, Virginia Eman Wheeless, Fran Dickson-Markman, A Research Note The Relations Among Social and Task Perceptions in Small Groups Small Group Research. ,vol. 13, pp. 373- 384 ,(1982) , 10.1177/104649648201300307
J. Groeschke, I. Solassol, F. Bressolle, F. Pinguet, Stability of amphotericin B and nystatin in antifungal mouthrinses containing sodium hydrogen carbonate. Journal of Pharmaceutical and Biomedical Analysis. ,vol. 42, pp. 362- 366 ,(2006) , 10.1016/J.JPBA.2006.04.011
R. Verdolini, L. Bugatti, G. Filosa, B. Mannello, F. Lawlor, R. R. Cerio, Old fashioned sodium bicarbonate baths for the treatment of psoriasis in the era of futuristic biologics: an old ally to be rescued. Journal of Dermatological Treatment. ,vol. 16, pp. 26- 30 ,(2005) , 10.1080/09546630410024862