Insect ion transport peptides are derived from alternatively spliced genes and differentially expressed in the central and peripheral nervous system

摘要: Insect ionic and fluid homeostasis relies upon the Malpighian tubules (MT) different hindgut compartments. Primary urine formed in MTs is finally modified by ion, solute water reabsorptive processes primarily under control of several large peptide hormones. One these, ion transport (ITP), a chloride transport-stimulating acid secretion-inhibiting hormone similar to crustacean hyperglycaemic hormones (CHHs). In locusts, moths fruit flies, ITP together with slightly longer ITPL isoforms, inactive bioassays, arise alternative splicing from very itp genes. are differentially distributed (1) pars lateralis/retrocerebral complex neurosecretory cells (NSCs) containing both splice forms, (2) interneurons either one (3) hindgut-innervating abdominal neurons (in Drosophila only), (4) intrinsic, putative sensory NSCs peripheral neurohaemal perisympathetic/perivisceral organs or transverse nerves (usually ITPL). Both forms occur as released into haemolymph response feeding stress stimuli. mainly discussed competitive inhibitor (as established vitro) action on yet be identified receptors. Furthermore, some evidence has been provided for possible ecdysis-related functions and/or moths. The comparative data highly gene, precursor primary structures differential distributions insect suggest that CHH/ITP neuropeptide-producing their gene products share common phylogenetic ancestry.