Comparison of the volumetric and radiomics findings of 18F-FDG PET/CT images with immunohistochemical prognostic factors in local/locally advanced breast cancer.

摘要: Objective The aim of this study was to determine the change in volumetric and radiomics parameters fluorine-18 fluorodeoxyglucose (F-FDG) PET/computed tomography (CT) imaging local/locally advanced cancer patients according immunohistochemical findings. Patients methods A total 72 who were diagnosed with breast then examined by F-FDG PET/CT for staging included study. Immunohistochemical prognostic factors [estrogen receptor (ER), progesterone (PR), human epidermal growth factor 2 (Her-2), p53 mutation, Ki-67 proliferation index] histological grades determined. Standardized uptake value (SUV)-based, volume-based, findings obtained from images. Results In cases ER PR negativity, Her-2 positivity, presence index at least 20% patients, significantly higher paired comparisons. results ER-negative group than those ER-positive GLRLM_GLNU, GLRLM_RLNU, GLZLM_GLNU, GLZLM_ZLNU grade 3 mean SUV, maximum GLRLM_LRHGE values patients. SUV less 20%. Maximum tumor lesion glycolysis values, entropy nuclear polymorphism 3+ patient found be compared 2+ group. Moreover, mitosis had metabolic volume, glycolysis, kurtosis 1+ Conclusion triple high grade, associated heterogeneity. With respect number, index, an increased load observed. addition parameters, use data is believed contribute management.