Association between semiquantitative Pet parameters and molecular subtypes of breast invasive ductal carcinoma.

摘要: BACKGROUND Molecular subtypes of breast cancer have been proposed since 2012. The correlation between various baseline [18F]fluorodeoxyglucose ([18F]FDG) uptake parameters, including total lesion glycolysis (TLG), and molecular primary lesions in patients with invasive ductal will be investigated. METHODS Staging [18F]FDG PET/CT for carcinoma were retrospectively evaluated. Breast examined estrogen receptor (ER), progesterone (PR), human epidermal growth factor 2 (HER2) proliferation index (Ki-67). tumors classified into five subtypes: Luminal A, B-HER2(-), B-HER2(+), HER2(+) Basal or Triple Negative cancers. correlations tumor characteristics PET semiquantitative data (SUVmean, SUVmax, Mean volume (MTV), TLG) assessed. Specific Uptake Ratio (SBUR) is used as a new quantification method to correct physiological background activity. RESULTS Fifty-eight included. TLG was significantly higher triple negative group when compared luminal A (P<0.01). Significantly found B-HER2(-) B-HER2(+) categories using SUVmean (all P<0.05). Conversely, no statistically significant difference observed all other subtypes. No value SBUR terms histopathological parameters demonstrated. CONCLUSIONS superior SUVmax differentiating not different