Hydroquinone inhibits PRV infection in neurons in vitro and in vivo.

摘要: Pseudorabies virus (PRV) is a prevalent and endemic swine pathogen that causes significant economic losses in the global industry. Due to emergence of PRV mutant strains recent years, vaccines can't completely prevent control infection. Therefore, research development new drugs with inhibitory effects on are great significance prevention treatment PR. In this study, we firstly screened library 44 FDA-approved found hydroquinone (HQ) displayed high anti-PRV activity by inhibiting adsorption onto internalization into cells. This study revealed stimulated genes associated PI3K-AKT signal pathway. HQ increased AKT mRNA production activated phosphorylation N2a finding suggests significantly inhibits replication activating AKT. We also conducted vivo experiments mice. Hydroquinone reduced viral loads mouse tissues mortality after The above results indicate strain ZJ01 ICR mice has an effect PRV. will contribute novel prophylactic therapeutic strategy against