Liver graft preconditioning, preservation and reconditioning

摘要: Liver transplantation is the successful treatment of end-stage liver disease; however, ischaemia-reperfusion injury still jeopardizes early and long-term post-transplant outcomes. In fact, associated with increased morbidity graft dysfunction, especially when suboptimal donors are utilized. Strategies to reduce severity can be applied at different steps process: organ procurement, preservation phase or before revascularization. During donor procedure, preconditioning consists pre-treating prior a sustained ischaemia either by transient period administration anti-ischaemic medication, although multi-pharmacological approach seems more promising. Different solutions were developed maintain viability during static cold storage, achieving substantial results in terms function survival good quality organs but not ones. Indeed, do prevent dysfunction poor burdened inadequate biliary epithelium. Advantages derived from hypo- normothermic machine perfusion currently investigated experimental clinical settings, suggesting reconditioning effect possibly improving hepatocyte resuscitating transplantation. this review, we highlight acquired knowledge recent advances preconditioning, reconditioning.