Novel treatment opportunities for sulfur mustard-related cancers: genetic and epigenetic perspectives.
作者： Soheila Rahmani , Mohammad Abdollahi
DOI: 10.1007/S00204-017-2086-7
关键词:
摘要: Sulfur mustard (SM), also known as gas, is a chemical weapon which by now has been used in many wars. The most concerning SM toxic effect probable carcinogenicity. In this study, the genetic and epigenetic mechanisms of carcinogenicity, focusing on treatment SM-associated malignancies, particularly gene therapeutics, cancer vaccines, medications, have criticized. required data were collected through an organized search valid scientific databases. For carcinogenicity due to acute or chronic exposure, entire original review articles evaluated. addition, studies therapeutic effects available medications included. Currently, four two vaccines with bases, seven are for treatment. Genetic treatments including Gendicine, Imlygic, Provenge, Cimavax-EGF, Azacitidine, Vorinostat, Romidepsin, Belinostat will yield outstanding benefits SM-exposed patients who suffer from cancer.
springer.com
sci-hub.se 参考文章(165)
Oliver Goodyear, Angelo Agathanggelou, Igor Novitzky-Basso, Shamyla Siddique, Tina McSkeane, Gordon Ryan, Paresh Vyas, Jamie Cavenagh, Tanja Stankovic, Paul Moss, Charles Craddock, Induction of a CD8+ T-cell response to the MAGE cancer testis antigen by combined treatment with azacitidine and sodium valproate in patients with acute myeloid leukemia and myelodysplasia Blood. ,vol. 116, pp. 1908- 1918 ,(2010) , 10.1182/BLOOD-2009-11-249474
Honnavara N. Ananthaswamy, Susan M. Loughlin, Patricia Cox, Randall L. Evans, Stephen E. Ullrich, Margaret L. Kripke, Sunlight and skin cancer: Inhibition of p53 mutations in UV-irradiated mouse skin by sunscreens Nature Medicine. ,vol. 3, pp. 510- 514 ,(1997) , 10.1038/NM0597-510
Zhi-Qiang Ning, Zhi-Bin Li, Michael J. Newman, Song Shan, Xin-Hao Wang, De-Si Pan, Jin Zhang, Mei Dong, Xin Du, Xian-Ping Lu, Chidamide (CS055/HBI-8000): a new histone deacetylase inhibitor of the benzamide class with antitumor activity and the ability to enhance immune cell-mediated tumor cell cytotoxicity. Cancer Chemotherapy and Pharmacology. ,vol. 69, pp. 901- 909 ,(2012) , 10.1007/S00280-011-1766-X
Seyed Naser Emadi, Mohammadreza Mortazavi, Hossein Mortazavi, Late Cutaneous Manifestations 14 to 20 Years After Wartime Exposure to Sulfur Mustard Gas: A Long-term Investigation Archives of Dermatology. ,vol. 144, pp. 1059- 1061 ,(2008) , 10.1001/ARCHDERM.144.8.1059
Yukio Takeshima, Kouki Inai, William P. Bennett, Robert A. Metcalf, Judith A. Welsh, Shuji Yonehara, Yuzo Hayashi, Megumu Fujihara, Michio Yamakido, Mitoshi Akiyama, Shoji Tokuoka, Charles E. Land, Curtis C. Harris, p53 mutations in lung cancers from Japanese mustards gas workers Carcinogenesis. ,vol. 15, pp. 2075- 2079 ,(1994) , 10.1093/CARCIN/15.10.2075
Alboukadel Kassambara, Bernard Klein, Jérome Moreaux, MMSET is overexpressed in cancers: Link with tumor aggressiveness Biochemical and Biophysical Research Communications. ,vol. 379, pp. 840- 845 ,(2009) , 10.1016/J.BBRC.2008.12.093
A. Farkas, C. Conrad, G. Tonel, Z. Borbenyi, L. Kemeny, A. Dobozy, F.O. Nestle, Current state and perspectives of dendritic cell vaccination in cancer immunotherapy. Skin Pharmacology and Physiology. ,vol. 19, pp. 124- 131 ,(2006) , 10.1159/000092592
Karen Chiam, Carmela Ricciardelli, Tina Bianco-Miotto, Epigenetic biomarkers in prostate cancer: Current and future uses Cancer Letters. ,vol. 342, pp. 248- 256 ,(2014) , 10.1016/J.CANLET.2012.02.011
D. Ibraheem, A. Elaissari, H. Fessi, Gene therapy and DNA delivery systems International Journal of Pharmaceutics. ,vol. 459, pp. 70- 83 ,(2014) , 10.1016/J.IJPHARM.2013.11.041
R. Bruvere, G. Feldmane, A. Ferdats, O. Heisele, A. Muceniece, Adjuvant immunotheraphy with virus-mediated biomodulators developed in Latvia: experimental and clinical data Melanoma Research. ,vol. 16, ,(2006) , 10.1097/00008390-200609001-00058