Effects of Acute Tryptophan Depletion on Mood and Cortisol Release in First-degree Relatives of Type I and Type II Bipolar Patients and Healthy Matched Controls
作者： S Sobczak , A Honig , NA Nicolson , WJ Riedel
DOI: 10.1016/S0893-133X(02)00345-7
关键词:
摘要: Biological vulnerability for bipolar disorders (BD) in relatives of BD patients has not as yet been established. Serotonergic was studied, using acute tryptophan depletion (ATD), healthy first-degree and controls. The effects ATD on mood cortisol release 30 adult, lifetime symptom free, unaffected (Family History; FH) were compared with 15 matched controls a placebo-controlled, double-blind, crossover design. During placebo, salivary response also assessed during stress-inducing speech task (SIST). First-degree type II (FH II) showed an elevation mood, whereas control subjects I I) lowering after ATD. followed by decrease level both FH subgroups, but the results suggest serotonergic that affected subjects.
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