Impairment of verbal learning and memory and executive function in unaffected siblings of probands with bipolar disorder.

摘要: Kulkarni S, Jain Janardhan Reddy YC, Kumar KJ, Kandavel T. Impairment of verbal learning and memory executive function in unaffected siblings probands with bipolar disorder. Bipolar Disord 2010: 12: 647–656. © 2010 The Authors. Journal compilation John Wiley & Sons A/S. Objectives:  Impairments have been reported relatives patients disorder, suggesting that they could be potential endophenotypes for genetic studies, but the findings are inconsistent. In this study, neuropsychological performance family loading disorder is compared to individually matched healthy controls. We hypothesized on tests functions would impaired controls. Methods:  evaluated 30 I controls using attention, function, memory. Unaffected control subjects did not differ respect gender, age, years education. Results:  performed poorly Tower London test (TOL), Rey’s auditory (RAVLT), complex figure test. multivariate analysis, significance was noted TOL, total number moves (p = 0.007) RAVLT score 0.001). Conclusions:  Our study suggests deficits (planning) These consistent proposed neurobiological model involving frontotemporal subcortical circuits. Future studies couple cognitive imaging strategies genomics identify neurocognitive