Platinum(II) O,S complexes as potential metallodrugs against Cisplatin resistance
作者： Jana Hildebrandt , Norman Häfner , Helmar Görls , Daniel Kritsch , Giarita Ferraro
DOI: 10.1039/C6DT01388K
关键词:
摘要: We report on platinum(II) complexes with different cinnamic acid derivatives as ligands cytotoxic activity against Cisplatin resistant ovarian cancer cell line subcultures of SKOV3 and A2780. A typical mechanism action for itself is binding to the DNA inducing double-strand breaks. examined biological behavior these potential drugs 9-methylguanine using NMR spectroscopic methods their damage including γH2AX-foci analyses. X-ray diffraction have been used elucidate molecular structures complexes. Interactions model protein lysozyme evaluated by techniques UV-Vis absorption spectroscopy, fluorescence crystallography.
rsc.org
rcsb.org参考文章(57)
Garib N. Murshudov, Pavol Skubák, Andrey A. Lebedev, Navraj S. Pannu, Roberto A. Steiner, Robert A. Nicholls, Martyn D. Winn, Fei Long, Alexei A. Vagin, REFMAC5 for the refinement of macromolecular crystal structures Acta Crystallographica Section D-biological Crystallography. ,vol. 67, pp. 355- 367 ,(2011) , 10.1107/S0907444911001314
Christian G. Hartinger, Paul J. Dyson, Bioorganometallic chemistry—from teaching paradigms to medicinal applications Chem. Soc. Rev.. ,vol. 38, pp. 391- 401 ,(2009) , 10.1039/B707077M
Airlie J. McCoy, Ralf W. Grosse-Kunstleve, Paul D. Adams, Martyn D. Winn, Laurent C. Storoni, Randy J. Read, Phaser crystallographic software Journal of Applied Crystallography. ,vol. 40, pp. 658- 674 ,(2007) , 10.1107/S0021889807021206
Luigi Messori, Tiziano Marzo, Elena Michelucci, Irene Russo Krauss, Carmen Navarro-Ranninger, Adoracion G. Quiroga, Antonello Merlino, Interactions between Anticancer trans-Platinum Compounds and Proteins: Crystal Structures and ESI-MS Spectra of Two Protein Adducts of trans-(Dimethylamino)(methylamino)dichloridoplatinum(II). Inorganic Chemistry. ,vol. 53, pp. 7806- 7808 ,(2014) , 10.1021/IC5012583
Xinjian Lin, Tsuyoshi Okuda, Alison Holzer, Stephen B. Howell, The copper transporter CTR1 regulates cisplatin uptake in Saccharomyces cerevisiae. Molecular Pharmacology. ,vol. 62, pp. 1154- 1159 ,(2002) , 10.1124/MOL.62.5.1154
Carolin Mügge, Tiziano Marzo, Lara Massai, Jana Hildebrandt, Giarita Ferraro, Pablo Rivera-Fuentes, Nils Metzler-Nolte, Antonello Merlino, Luigi Messori, Wolfgang Weigand, None, Platinum(II) Complexes with O,S Bidentate Ligands: Biophysical Characterization, Antiproliferative Activity, and Crystallographic Evidence of Protein Binding Inorganic Chemistry. ,vol. 54, pp. 8560- 8570 ,(2015) , 10.1021/ACS.INORGCHEM.5B01238
Giuliano Ciarimboli, Membrane transporters as mediators of cisplatin side-effects. Anticancer Research. ,vol. 34, pp. 547- 550 ,(2014)
Andrea Genazzani, S Cosio, Angiolo Gadducci, S Muraca, Molecular mechanisms of apoptosis and chemosensitivity to platinum and paclitaxel in ovarian cancer: biological data and clinical implications. European Journal of Gynaecological Oncology. ,vol. 23, pp. 390- 396 ,(2002)
Zbyszek Otwinowski, Wladek Minor, Processing of X-ray diffraction data collected in oscillation mode Methods in Enzymology. ,vol. 276, pp. 307- 326 ,(1997) , 10.1016/S0076-6879(97)76066-X
Norman Häfner, Daniel Steinbach, Lars Jansen, Herbert Diebolder, Matthias Dürst, Ingo B. Runnebaum, RUNX3 and CAMK2N1 hypermethylation as prognostic marker for epithelial ovarian cancer. International Journal of Cancer. ,vol. 138, pp. 217- 228 ,(2016) , 10.1002/IJC.29690