Engineered Liver-on-a-Chip Platform to Mimic Liver Functions and Its Biomedical Applications: A Review.

作者: Deng , Wei , Chen , Lin , Zhao

DOI: 10.3390/MI10100676

关键词:

摘要: … critical phase I metabolic enzymes in drug metabolism of the liver. … all aspects of drug phase I metabolism, including oxidation, … randomly without formation of spatial organization ie, liver …

参考文章(111)
Knut Rennert, Sandra Steinborn, Marko Gröger, Birgit Ungerböck, Anne-Marie Jank, Josef Ehgartner, Sandor Nietzsche, Julia Dinger, Michael Kiehntopf, Harald Funke, Frank T. Peters, Amelie Lupp, Claudia Gärtner, Torsten Mayr, Michael Bauer, Otmar Huber, Alexander S. Mosig, A microfluidically perfused three dimensional human liver model. Biomaterials. ,vol. 71, pp. 119- 131 ,(2015) , 10.1016/J.BIOMATERIALS.2015.08.043
Mi Jang, Pavel Neuzil, Thomas Volk, Andreas Manz, Astrid Kleber, On-chip three-dimensional cell culture in phaseguides improves hepatocyte functions in vitro. Biomicrofluidics. ,vol. 9, pp. 034113- 034113 ,(2015) , 10.1063/1.4922863
Lawrence A Vernetti, Nina Senutovitch, Robert Boltz, Richard DeBiasio, Tong Ying Shun, Albert Gough, D Lansing Taylor, A human liver microphysiology platform for investigating physiology, drug safety, and disease models. Experimental Biology and Medicine. ,vol. 241, pp. 101- 114 ,(2016) , 10.1177/1535370215592121
Ilka Maschmeyer, Alexandra K. Lorenz, Katharina Schimek, Tobias Hasenberg, Anja P. Ramme, Juliane Hübner, Marcus Lindner, Christopher Drewell, Sophie Bauer, Alexander Thomas, Naomia Sisoli Sambo, Frank Sonntag, Roland Lauster, Uwe Marx, A four-organ-chip for interconnected long-term co-culture of human intestine, liver, skin and kidney equivalents Lab on a Chip. ,vol. 15, pp. 2688- 2699 ,(2015) , 10.1039/C5LC00392J
Da Yoon No, Kwang-Ho Lee, Jaeseo Lee, Sang-Hoon Lee, 3D liver models on a microplatform: well-defined culture, engineering of liver tissue and liver-on-a-chip Lab on a Chip. ,vol. 15, pp. 3822- 3837 ,(2015) , 10.1039/C5LC00611B
Rui M. Tostões, Sofia B. Leite, Margarida Serra, Janne Jensen, Petter Björquist, Manuel J. T. Carrondo, Catarina Brito, Paula M. Alves, Human liver cell spheroids in extended perfusion bioreactor culture for repeated-dose drug testing. Hepatology. ,vol. 55, pp. 1227- 1236 ,(2012) , 10.1002/HEP.24760
Ilka Maschmeyer, Tobias Hasenberg, Annika Jaenicke, Marcus Lindner, Alexandra Katharina Lorenz, Julie Zech, Leif-Alexander Garbe, Frank Sonntag, Patrick Hayden, Seyoum Ayehunie, Roland Lauster, Uwe Marx, Eva-Maria Materne, Chip-based human liver-intestine and liver-skin co-cultures--A first step toward systemic repeated dose substance testing in vitro. European Journal of Pharmaceutics and Biopharmaceutics. ,vol. 95, pp. 77- 87 ,(2015) , 10.1016/J.EJPB.2015.03.002
Minjun Chen, Ayako Suzuki, Jürgen Borlak, Raúl J. Andrade, M Isabel Lucena, Drug-induced liver injury: Interactions between drug properties and host factors Journal of Hepatology. ,vol. 63, pp. 503- 514 ,(2015) , 10.1016/J.JHEP.2015.04.016
Jean-Matthieu Prot, Andrei Bunescu, Bénédicte Elena-Herrmann, Caroline Aninat, Leila Choucha Snouber, Laurent Griscom, Florence Razan, Frederic Y. Bois, Cécile Legallais, Céline Brochot, Anne Corlu, Marc Emmanuel Dumas, Eric Leclerc, Predictive toxicology using systemic biology and liver microfluidic "on chip" approaches: application to acetaminophen injury. Toxicology and Applied Pharmacology. ,vol. 259, pp. 270- 280 ,(2012) , 10.1016/J.TAAP.2011.12.017
Debra Laskin, Nonparenchymal cells and hepatotoxicity. Seminars in Liver Disease. ,vol. 10, pp. 293- 304 ,(1990) , 10.1055/S-2008-1040485