Differential effects of amino acids on the isolated perfused rat kidney.

摘要: 1. The direct effects of individual amino acids, including glycine (a neutral acid), l-glutamic acid (an acidic l-leucine neutral, branched-chain acid) and l-arginine basic on renal function were compared with a mixed solution by using the isolated rat kidney perfused physiological saline containing 6.7% (w/v) albumin basal level 2 mmol/l acids. 2. In control series, perfusate flow was stable but glomerular filtration rate, as measured [ 14 C]inulin clearance, declined time. A rate could be obtained increasing concentration to mmol/l. 3. addition 6 acids produced sustained increase in an reversing its time-dependent fall. Sodium reabsorption enhanced, but, unlike no fractional excretion obtained. 4. Renal increased (6 mmol/l), hydrochloride mmoll) sodium glutamate mmol/l) remained unaffected l-leucine. vasodilatation induced not sustained. 5. fall clearance prevented glycine, glutamic acid, l-Arginine hydrochloride, like solution, significant clearance. 6. l-leucine, decreased hydrochloride. seen series was, however, reversed all 7. results indicate that can produce hyperfiltration effect kidney, independent release systemic hormones. Individual differ their contribution response elicited solution. use mimic dietary protein vivo may therefore inappropriate.