What does the renal reserve mean

摘要: The concept of the renal functional reserve stems from observation that in normal humans, "resting" glomerular filtration rate may be acutely raised following several stimuli. This extra excretory capacity, represented by rise GFR baseline to maximum, might regarded as a upon which kidney could call times stress. As corollary it seemed likely whenever was damaged and lost this unused would depleted before resting fell. Measuring degree respond stress—its (RFR)—would therefore provide an early measure damage. It also rational believe once impaired response lost. Since hypothesis proposed has become obvious flawed. been clearly shown is not disease states its does represent true "reserve". itself heterogeneous. can induced variety stimuli using different mechanisms. most commonly used test RFR are high protein meal or intravenous (or oral) amino acid infusion. Dopamine infusions have provoke response, but there little evidence mediated same way. article will chiefly deal with physiological mechanisms involved haemodynamic meat infusion confine these responses convenient appellation "renal reserve".