Renal Haemodynamic and Hormonal Responses to a Mixed High-Protein Meal in Normal Men

摘要: Studies in normal man have demonstrated an acute increase glomerular filtration rate (GFR) and renal blood flow (RBF) after a mixed protein meal, but the hormonal mechanisms underlying this response are not well defined. Thirteen adult men were starved for 24 h, then fed test meal containing 1.5 g/kg bodyweight of animal protein. Renal haemodynamics plasma urinary hormones measured before at 2 h 4 meal. GFR RBF increased by 27% 23% respectively h. Electrolyte excretion did parallel was independent haemodynamic changes. Plasma noradrenaline (median 350 versus 573 pg/ml), renin (0.64 1.09 nmol AngI/l per h), prostaglandin E (PGE) (66.4 238 pmol/min) all significantly elevated In further experiments, nine subjects given indomethacin 50 mg using same protocol as before. comparison with control data, PGE remained baseline values. affected. These results suggest that to feeding is partly mediated intrarenal prostaglandins also part more complex interaction sympathetic nervous system.