摘要: Our understanding of cancer biology has been radically transformed over recent years with a more realistic grasp its multilayered cellular and genetic complexity. These advances are being translated into selective effective treatment cancers and, although there still considerable challenges, particularly drug resistance metastatic disease, many patients otherwise lethal malignancies now enjoy protracted remissions or cure. One largely unheralded theme this story is the extent to which new biological insights novel clinical applications have their origins leukaemia related blood cell cancers, including lymphoma. In Timeline article, I review remarkable ground-breaking role that studies in had at forefront progress.