How Can Gastric Cancer Molecular Profiling Guide Future Therapies?

摘要: Gastric cancer is the third greatest global cause of cancer-related deaths. Despite its high prevalence, only recently have comprehensive genomic surveys shed light on molecular alterations. As surgery curative treatment strategy and chemotherapy has shown limited efficacy, new treatments are urgently needed. Many therapies for gastric entered clinical trials but–apart from Trastuzumab Ramucirumab–all failed. We analyze current knowledge genetic ‘landscape’ cancers, elaborating novel, preclinical approaches. posit that this lays basis identifying bona fide targets developing solid therapeutic approaches, requiring accurate patient selection taking advantage models to assist development novel combination strategies.