Contribution of orosensory stimulation to strain differences in oil intake by mice

摘要: Little is known about why animals differ in daily intake of oils. Here, we tested the hypothesis that oral acceptability oil a key determinant intake. To this end, examined short- and long-term ingestive responses eight mouse strains (FVB/NJ, SWR/J, SM/J, C57BL/6J, BALB/cJ, 129P3/J, DBA/2J AKR/J) to Intralipid, stable emulsion soybean oil. In Experiment 1, compared orosensory responsiveness (as indicated by initial licking rates) range concentrations Intralipid sucrose. We included sucrose because there are two natural alleles Tas1r3 (the gene encodes T1R3 sweet taste receptor), with Tas1r3Sac-b allele exhibit higher than Tas1r3Sac-d allele. All exhibited concentration-dependent increases lick rates for both but extent these varied greatly across strains. The licked more vigorously at < or =0.3 M, not any concentration. 2, ran mice through 24-h preference tests, which they had choice between water each four (1, 5, 10 20%). differed particularly 1 5% concentrations. Regression analyses revealed strain differences reliably predicted 20% Intralipid. These findings indicate (i) genotype does modulate stimulation from oil, (ii) contributes dilute emulsions, concentrated ones, (iii) emulsions controlled primarily post-oral satiety mechanisms.