An experimental mouse testicular teratoma as a model for neuroepithelial neoplasia and differentiation. II. Electron microscopy.

摘要: The electron microscopic features of the stages divergent neuroepithelial differentiation in solid implants a transplantable mouse testicular teratoma (OTT-6050) are presented and compared to sequential cytogenesis that have been described developing avian mammalian central nervous system. Primitive tumor cells showed undifferentiated multipotential matrix (or ventricular) neural tube. They formed primitive medullary rosettes, from which various transitions were traced more differentiated, cilia-containing ependymoblastomatous rosettes; transitional included increased granular endoplasmic reticulum microvilli formation. Glial was characterized by presence mature ependymal rosettes astrocytes containing glial filaments. Neuronal development synapses dense-core vesicles nerve cell processes. No intermediate forms found suggested multiple lines occurring within single cell.